Thrombophilia is not a disease in itself. It is a different set of inherited and acquired coagulation disorders associated with a tendency to thrombosis.
Pregnancy is a condition in which the tendency to blood clotting is increased (increased production of fibrinogen, increased number of blood clotting factors – FII, FVII, FVIII, FX, FXII, increased level of PAI-1, decreased fibrinolysis, significantly reduced level of protein S, and acquired resistance to activated protein C) also occurs.
Congenital and acquired thrombophilia are associated with the risk of impaired pregnancy.
Known obstetric complications of thrombophilia include intrauterine fetal death, recurrent miscarriages, intrauterine fetal growth retardation, preeclampsia, placental abruption, and preterm birth.
Early pregnancy loss is the most common complication in pregnancy.
About 15% of all clinically recognized pregnancies end in miscarriage, and recurrent miscarriages occur in 1% of couples.